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1 year ago

The Historical Past Behind Zonisamide

Cancer stem cells (CSCs) are a subpopulation The History Of The Zonisamide of tumor cells suggested to be important for tumor upkeep, metastasis, and therapeutic resistance. Prospective identification and targeting of CSCs are thus priorities for the improvement of novel therapeutic paradigms. Though CSC enrichment continues to be attained with cell Historical Past Linked To Ponatinib surface proteins including CD133 (Prominin-1), the roles of current CSC markers in tumor maintenance remain unclear. We examined the glioblastoma stem cell (GSC) perivascular microenvironment in patient specimens to determine enrichment markers that has a practical significance and identified integrin alpha six like a candidate. Integrin alpha six is coexpressed with conventional GSC markers and enriches for GSCs. Targeting integrin alpha six in GSCs inhibits self-renewal, proliferation, and tumor formation capacity. Our effects give evidence that GSCs express substantial amounts of integrin alpha 6, which could serve not simply as an enrichment History Of Zonisamide marker but also as a promising antiglioblastoma treatment.